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The Role of Lipids in the Classification of Astrocytoma and Glioblastoma Using Mass Spectrometry Tumor Profiling
- Source :
- Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry. 15:153-160
- Publication Year :
- 2021
- Publisher :
- Pleiades Publishing Ltd, 2021.
-
Abstract
- Express MS identification of biological tissues has become a much more accessible research method due to the application of direct specimen ionization at atmospheric pressure. In contrast to traditional methods of analysis employing GC-MS methods for determining the molecular composition of the analyzed objects it eliminates the influence of mutual ion suppression. Despite significant progress in the field of direct MS of biological tissues, the question of mass spectrometric profile attribution to a certain type of tissue still remains open. The use of modern machine learning methods and protocols (e.g., “random forests”) enables us to trace possible relationships between the components of the sample MS profile and the result of brain tumor tissue classification (astrocytoma or glioblastoma). In this study it has been shown that the most pronounced differences in the mass spectrometric profiles of these tumors are due to their lipid composition. Detection of statistically significant differences in lipid profiles of astrocytoma and glioblastoma may be used to perform an express analysis during surgery and inform the neurosurgeon what type of malignant tissue he is working with. The ability of accurate determination of the tumor boundaries significantly improves the quality of surgical intervention and postoperative rehabilitation, as well as the duration and quality of life of patients.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
030102 biochemistry & molecular biology
business.industry
Clinical Biochemistry
Brain tumor
Astrocytoma
Ion suppression in liquid chromatography–mass spectrometry
Postoperative rehabilitation
medicine.disease
Mass spectrometry
Biochemistry
Mass spectrometric
03 medical and health sciences
030104 developmental biology
medicine
Molecular Medicine
business
Research method
Glioblastoma
Subjects
Details
- ISSN :
- 19907516 and 19907508
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry
- Accession number :
- edsair.doi...........7282b44cbec56dc134a26e41e6ca4f05