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Synthesis of nanostructured Ag@SiO2-Penicillin from high purity Ag NPs prepared by electromagnetic levitation melting process
- Source :
- Materials Science and Engineering: C. 102:616-622
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Nanostructured Ag@SiO2-Penicillin was synthesized from high-purity Ag0 NPs with a mean particle size of about 10 nm produced by electromagnetic levitation gas condensation (ELGC) method. The silver and penicillin contents of the synthesized nano-antibiotic were about 34 wt% and 2.5 wt% respectively, as determined by ICP-OES and TGA analyses. The antibacterial properties and synergistic effects of nanostructured Ag@SiO2 and Ag@SiO2–Penicillin on killing the Methicillin-susceptible S. aureus (MSSA) and Methicillin-resistant S. aureus (MRSA) bacteria were also examined. The nanoparticles were characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). Ag@SiO2-Penicillin NPs showed an outstanding antibacterial activity compared to Penicillin and Ag@SiO2 NPs. The Fractional inhibitory concentration (FIC) indexes were 0.54 and 0.52 against MSSA and MRSA bacteria respectively, illustrating the synergistic effects of Ag@SiO2-Penicillin NPs. In addition, Ag@SiO2-Penicillin NPs showed promising dose-dependent cytotoxicity effects indicating the protective effects emanating from anti-inflammatory properties of penicillin.
- Subjects :
- Materials science
biology
Nanoparticle
Bioengineering
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
biology.organism_classification
01 natural sciences
Silver nanoparticle
0104 chemical sciences
Biomaterials
Penicillin
Mechanics of Materials
Transmission electron microscopy
polycyclic compounds
medicine
Particle size
0210 nano-technology
Cytotoxicity
Antibacterial activity
Bacteria
Nuclear chemistry
medicine.drug
Subjects
Details
- ISSN :
- 09284931
- Volume :
- 102
- Database :
- OpenAIRE
- Journal :
- Materials Science and Engineering: C
- Accession number :
- edsair.doi...........7264f9760b0889d639f84ce56e328cbf