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Evaluation of anti-tumor activity of water-soluble polysaccharides from Dendrobium denneanum
- Source :
- African Journal of Pharmacy and Pharmacology. 5:415-420
- Publication Year :
- 2011
- Publisher :
- Academic Journals, 2011.
-
Abstract
- Three water-soluble polysaccharides (DDP1-1, DDP2-1 and DDP3-1) were obtained from the aqueous extracts of the stems of Dendrobium denneanum by hot water extraction, ethanol precipitation, and fractionated by DEAE-cellulose ion exchange chromatography and Sephadex G-200 gel filtration chromatography. The main structure characterizations and anti-tumor activities of three fractions were evaluated in this paper. The results showed DDP1-1 with 12.50 mg/kg could significant inhibit the increment of the tumor, increase immune index of S180 mice, and also strongly promote the secretion of IL-2, TNF-α and IFN-γ. Therefore, results of these studies demonstrated the polysaccharide DDP1-1 has strong anti-tumor and immunomodulation abilities. Key words: Immunomodulating, Dendrobium denneanum, polysaccharide, anti-tumor.
Details
- ISSN :
- 19960816
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- African Journal of Pharmacy and Pharmacology
- Accession number :
- edsair.doi...........7257a12ce817ebaa0e31674aef250cd4