Preliminary Screening of Ethanolic Extracts of Clausena anisata for Anticonvulsant Activity

The ethanol extracts of leaves, root bark and stem bark of Clausena anisata were tested for their ability to control convulsion induced by pentylenetetrazole in mice. Test animals were given sublethal but convulsive doses of pentylenetetrazole subcutaneously. The extracts tested were administered intraperitoneally in varying doses 2 h before pentylenetetrazole was administered. Of the three extracts, two (leaves and stem bark) were found to be ineffective in protecting the animals, but showed some sedative properties. The third (root bark) exhibited partial protection at a dose level of 800 mg/kg of mice. Keywords: Clausena anisata , Anticonvulsant activity, Ethanolic extracts of leaves, root bark, stem bark.