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Activity of vancomycin release from bioinspired coatings of hydroxyapatite or TiO 2 nanotubes
- Source :
- International Journal of Pharmaceutics. 517:296-302
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Herein we investigate the efficiency of various biomimetic coatings for localized drug delivery, using vancomycin as key therapeutic drug, which is a widely used antibiotic for the treatment of strong infections caused by positive Gram bacteria. We evaluate classical hydroxyapatite and biomimetic hydroxyapatite-collagen coatings obtained by electrochemical deposition as well as TiO2 nanotubes arrays obtained by electrochemical anodization. Surface morphology, compositional and structural data confirm the incorporation of vancomycin into the layers and drug release profiles for vancomycin evaluate their release ability. Namely, hydroxyapatite coatings lead to a ≈92% vancomycin release after 30h and hydroxyapatite-collagen to 85%, while the TiO2 nanotubes layers lead to 78% release. The antibacterial effect of such drug loaded coatings is evaluated against S. aureus (Gram-positive bacteria). Our study shows that the vancomycin incorporated hydroxyapatite coatings lead to a faster release, while the nanotubular coatings may lead to longer time release and additionally both types of coatings ensure a good antibacterial inhibition.
- Subjects :
- Time release technology
Materials science
Drug Liberation
Pharmaceutical Science
chemistry.chemical_element
02 engineering and technology
Antibacterial effect
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Electrochemical anodization
0104 chemical sciences
Microbiology
Chemical engineering
chemistry
Drug delivery
medicine
Hydroxyapatite coating
Vancomycin
0210 nano-technology
medicine.drug
Titanium
Subjects
Details
- ISSN :
- 03785173
- Volume :
- 517
- Database :
- OpenAIRE
- Journal :
- International Journal of Pharmaceutics
- Accession number :
- edsair.doi...........7242046c03ff0cf091c65c897aeaeab3