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The role of prostatic urethral biopsies as a staging tool for bladder cancer
- Source :
- Journal of Clinical Urology. 10:359-363
- Publication Year :
- 2016
- Publisher :
- SAGE Publications, 2016.
-
Abstract
- Objective: To determine the incidence of prostatic urethral involvement in our patient population and how prostatic urethral biopsy correlates with final cystectomy pathology. Patients and methods: We conducted a retrospective review of prostatic urethral biopsies (PUB) performed between February 2008 and April 2012 in a single centre. PUB pathology was correlated with cystectomy pathology. Results: PUB was undergone by 172 patients with a median age of 70 years (range: 37–84 years): There were 35 (20%) patients having a positive PUB and 137 (80%) who were negative. Of the 94 patients who underwent cystectomy, we found that when the entire prostatic urethra was sectioned, 20 (21%) patients had cancer in the prostatic urethra. Cancer was found in 17 (77%) of 22 patients with a positive PUB and in three (4%) out of the 72 with a negative PUB (positive predictive value (PPV) 77%, negative predictive value (NPV) 96%, sensitivity 85% and specificity 93%). In all 94 patients, the prostatic apical margin was negative. Conclusion: Disease in the prostatic urethra affected 20% of patients, consistent with published data. Prostatic urethral apical margins were all negative. Intra-operative frozen section would have missed cancer in the 20 patients with prostatic urethral cancer, whereas PUB identified 17 (85%) of the 20 patients. These data confirm the value of using PUB before cystectomy, in our UK population.
- Subjects :
- medicine.medical_specialty
Bladder cancer
medicine.diagnostic_test
business.industry
Urology
medicine.medical_treatment
Incidence (epidemiology)
030232 urology & nephrology
Cancer
medicine.disease
Cystectomy
03 medical and health sciences
Patient population
0302 clinical medicine
Urethra
medicine.anatomical_structure
Prostate
030220 oncology & carcinogenesis
Biopsy
medicine
Surgery
business
Subjects
Details
- ISSN :
- 20514166 and 20514158
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Urology
- Accession number :
- edsair.doi...........71ed0c23c5fbed457e9728610c8fa46d