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Clinical outcomes after sirolimus-eluting stent implantation for de novo saphenous vein graft lesions
- Source :
- Catheterization and Cardiovascular Interventions. 65:208-211
- Publication Year :
- 2005
- Publisher :
- Wiley, 2005.
-
Abstract
- The purpose of this study was to evaluate the clinical outcome of patients undergoing sirolimus-eluting stent implantation for de novo lesions within saphenous vein grafts (SVGs). Although the incidence of restenosis following sirolimus-eluting stenting (SES) of native coronary arteries is low, the efficacy of SES to treat de novo lesions within SVGs has not been well studied. A total of 35 patients underwent SES implantation of 39 lesions during 36 procedures. All patients had a minimum follow-up of 6 months following the index procedure. The mean bypass graft age was 10.1 +/- 6.5 years (range, 0-23 years). In-hospital major adverse cardiac events [death, myocardial infarction, thrombosis, or target vessel revascularization (TVR)] occurred in four patients (11%). Clinical follow-up was obtained in 100% of patients (mean follow-up, 7.5 +/- 2.2 months). There was one cardiac death, presumed due to stent thrombosis. TVR occurred in only two patients (6%). Myocardial infarction (MI) occurred in four patients (11%), all attributable to a nontarget vessel. The combined endpoint of death, MI, or TVR occurred in seven patients (20%). Freedom from death, nonfatal MI, thrombosis, or any revascularization was 65%. Early experience indicates sirolimus-eluting stents for de novo saphenous vein graft lesions have a low (6%) rate of clinically driven target vessel revascularization. By 7-month follow-up, event-free survival is limited primarily by disease in nontarget vessels.
- Subjects :
- medicine.medical_specialty
business.industry
medicine.medical_treatment
General Medicine
Revascularization
medicine.disease
Balloon
Thrombosis
Surgery
Coronary arteries
Coronary artery disease
medicine.anatomical_structure
Restenosis
Internal medicine
Angioplasty
cardiovascular system
medicine
Cardiology
Radiology, Nuclear Medicine and imaging
Myocardial infarction
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15221946
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Catheterization and Cardiovascular Interventions
- Accession number :
- edsair.doi...........71b9e79d46ed3c57c09a0c7ea300bcac