Synthesis of Alkyl and Aryl Esters of N-Protected β-Homoamino Acids from N-Protected α-Aminodiazoketones

Authors :: Hosahudya N. Gopi
Ganga-Ramu Vasanthakumar
V V Suresh Babu
Source :: Protein & Peptide Letters. 9:529-532
Publication Year :: 2002
Publisher :: Bentham Science Publishers Ltd., 2002.
Abstract: A simple and concomitant esterification method for the synthesis of methyl, ethyl, t-butyl, benzyl, and 9-fluorenylmethyl esters of Fmoc-/Boc-/Z-beta-homoamino acids employing Fmoc-/Boc-/Z-alpha-aminodiazoketones by Wolff rearrangement is described. The method offers good yield with purity.

Subjects :: chemistry.chemical_classification
chemistry.chemical_compound
chemistry
Structural Biology
Aryl
Yield (chemistry)
Organic chemistry
Wolff rearrangement
General Medicine
Biochemistry
Alkyl

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