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Ca2+-Triggered Synaptic Vesicle Fusion Initiated by Release of Inhibition
- Source :
- Trends in Cell Biology. 28:631-645
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Recent structural and functional studies of the synaptic vesicle fusion machinery suggest an inhibited tripartite complex consisting of neuronal soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs), synaptotagmin, and complexin prior to Ca2+-triggered synaptic vesicle fusion. We speculate that Ca2+-triggered fusion commences with the release of inhibition by Ca2+ binding to synaptotagmin C2 domains. Subsequently, fusion is assisted by SNARE complex zippering and by active membrane remodeling properties of synaptotagmin. This additional, inhibitory role of synaptotagmin may be a general principle since other recent studies suggest that Ca2+ binding to extended synaptotagmin C2 domains enables lipid transport by releasing an inhibited state of the system, and that Munc13 may nominally be in an inhibited state, which is released upon Ca2+ binding to one of its C2 domains.
- Subjects :
- 0301 basic medicine
endocrine system
Synaptotagmin I
Cell Biology
Biology
Synaptic vesicle
Fusion protein
Synaptotagmin 1
03 medical and health sciences
030104 developmental biology
nervous system
Complexin
Biophysics
lipids (amino acids, peptides, and proteins)
Binding site
SNARE complex
Synaptic vesicle priming
Subjects
Details
- ISSN :
- 09628924
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Trends in Cell Biology
- Accession number :
- edsair.doi...........7128f74ca0b7afdbd4ca2980e2f66af5