Abstract 16040: Corin Reduces Myocardial Infarction and Protects Against Cardiomyocyte Apoptosis

Corin is a cardiac-selective membrane protease that activates pro-ANP and pro-BNP. Emerging evidence suggests that corin may be a key biomarker and modulator of heart failure in dilated cardiomyopathy, but there is little known about the role of corin in myocardial infarction (MI). In acute MI in mice, we found that corin transcript and protein levels were significantly decreased when compared to non-MI controls 24 hrs post MI (1.0±0.1 vs 0.6±0.1, p=0.01; 1.0±0.04 vs 0.5±0.1, p2 , 261±13 vs 106±16, p