Novel and Experimental Therapies on the Horizon

Celiac disease (CD) is an enteropathy-induced immune response that occurs on exposure to toxic gluten in the diet and is reversible in most cases once gluten is withdrawn. A gluten-free diet (GFD) is the preferred treatment for CD and leads to reversal of villous atrophy. Individuals with untreated CD may experience significant health complications. Managing CD can potentially prevent or cure some of the associated conditions, such as neurologic complications, nutritional deficiencies, and osteoporosis. Counseling, nutritional support, and follow-up are vital aspects in CD management. GFD remains the mainstay of treatment in CD. Adhering to a strict GFD remains challenging for some individuals, and it has its limitations and other alternatives are called for. There are new and novel treatments emerging, which will be discussed here.