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Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the literature
- Source :
- Child's Nervous System. 38:465-472
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Wnt-activated medulloblastoma (MB) confers an excellent prognosis. However, specific treatment strategies for patients with relapsed Wnt-MB are unknown. We report two patients with recurrent beta-catenin nucleopositive Wnt-MB successfully treated by incorporating marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue (HDCx/AuHPCR). We also present a review of the literature for previously reported cases of relapsed Wnt-MB. We propose that patients with recurrent Wnt-MB may be treated using a multi-disciplinary approach that includes HDCx/AuHPCR with or without re-irradiation.
- Subjects :
- Medulloblastoma
Oncology
medicine.medical_specialty
Chemotherapy
business.industry
medicine.medical_treatment
Cell
Wnt signaling pathway
General Medicine
medicine.disease
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Hematopoietic progenitor
030220 oncology & carcinogenesis
Internal medicine
Pediatrics, Perinatology and Child Health
Ablative case
medicine
Treatment strategy
Neurology (clinical)
Neurosurgery
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14330350 and 02567040
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Child's Nervous System
- Accession number :
- edsair.doi...........70180ce49a3950b7e14ed9c13c80ae7e