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Analysis of distinct SF3B1 hotspot mutations in relation to clinical phenotypes and response to therapy in myeloid neoplasia

Authors :
Yazan F. Madanat
Teodora Kuzmanovic
Sudipto Mukherjee
Heesun J. Rogers
Anjali S. Advani
Aaron T. Gerds
Bhumika J. Patel
Yasunobu Nagata
Mikkael A. Sekeres
Yogen Saunthararajah
Cassandra M Kerr
Aziz Nazha
Jennifer S. Carew
Steffan T. Nawrocki
Hetty E. Carraway
Francesc Solé
Valeria Visconte
Ying Ni
Jack Khouri
Hassan Awada
Vera Adema
Jaroslaw P. Maciejewski
Source :
Leukemia & Lymphoma. 62:735-738
Publication Year :
2020
Publisher :
Informa UK Limited, 2020.

Abstract

Here we investigate single codon SF3B1 mutations (K700E, K666, H662) to identify whether discrete amino acid substitutions may influence clinical phenotypes, survival and response to treatments in ...

Details

ISSN :
10292403 and 10428194
Volume :
62
Database :
OpenAIRE
Journal :
Leukemia & Lymphoma
Accession number :
edsair.doi...........700c01c82a1a7cbec4041354cc9c7b1c