ChemInform Abstract: Tetrahydropyridine Derivatives with Inhibitory Activity on the Production of Proinflammatory Cytokines. Part 3

In order to develop a new class of anti-rheumatic drugs which inhibit production of proinflammatory cytokines such as TNFα, IL-1β, IL-6, and IL-8, a series of 3-pyridylpyrrole derivatives possessing a bicyclic tetrahydropyridine moiety at the 4-position of the pyrrole ring are synthesized and their pharmacological activities are evaluated.