Synthesis of d,l-β-carboxyaspartic acid from hydantoin-5-malonic acid diethyl ester

Authors :: Peter V. Hauschka
Paul M. Gallop
Edward Henson
Source :: Tetrahedron. 37:2561-2562
Publication Year :: 1981
Publisher :: Elsevier BV, 1981.
Abstract: Hydantoin-5-malonic acid diethyl ester was synthesized by reduction of parabanic acid (oxalyl urea) to 5-hydroxy-hydantoin, conversion to 5-chlorohydantoin and condensation with malonic ester. Alkaline hydrolysis gave d,l -β-carboxyaspartic acid.

Subjects :: chemistry.chemical_compound
chemistry
Organic Chemistry
Drug Discovery
Diethyl ester
Acetoacetic ester synthesis
Urea
Organic chemistry
Hydantoin
Parabanic acid
Malonic acid
Alkaline hydrolysis (body disposal)
Biochemistry

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