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Full Spectroscopic Characterization and Cytotoxicity Activity of Synthetic Dibenzalacetone Derivatives
- Source :
- Journal of Molecular Structure. 1231:129670
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Dibenzalacetone derivatives are organic compounds formed by two α , α ′ active sites that provide a large relocation of π-electrons. They have great polarizability that make them excellent chromophore and draw attention for their biological properties, mainly for their activity against nasopharyngeal, oral, colon, prostate and cervical cancer. Two dibenzalacetone derivatives, (1E,4E)-1,5-bis(4-ethoxyphenyl)penta-1,4-dien-3-one and (1E,4E)-1,5-bis(4-chlorophenyl)penta-1,4-dien-3-one, were synthesized. Spectroscopic characterizations as well as vibrational assignments were predicted using density Functional Theory (DFT) calculations with B3LYP exchange-correlation functional. Cytotoxicity assays of the synthesized compounds were performed against HCT-116, SNB and PC3 cells, showing promising results against cancer cells HCT-116.
- Subjects :
- 010405 organic chemistry
Chemistry
Organic Chemistry
Chromophore
010402 general chemistry
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
Analytical Chemistry
Characterization (materials science)
Inorganic Chemistry
Polarizability
Biological property
Cancer cell
Density functional theory
Cytotoxicity
Spectroscopy
Subjects
Details
- ISSN :
- 00222860
- Volume :
- 1231
- Database :
- OpenAIRE
- Journal :
- Journal of Molecular Structure
- Accession number :
- edsair.doi...........6e69e6565fefebecae1d327669ef217f