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Peritoneal sarcomatosis in pediatric malignancies
- Source :
- Pediatric Blood & Cancer. 60:12-17
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Peritoneal sarcomatosis (PSC) is defined as peritoneal involvement of multiple sarcomatous tumors. Desmoplastic small round cell tumors (DSRCT) and rhabdomyosarcomas are the most common pediatric PSC cases. PSC has been treated with chemotherapy and mainly palliative surgery, but long-term outcome has been poor. New imaging technologies have improved the evaluation of disease extent and patterns of peritoneal dissemination, and cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is being evaluated as a treatment option to prolong remission in pediatric patients. We will review the clinical characteristics, potential biologic mechanisms, radiographic characteristics, and potential therapies for pediatric PSC patients.
- Subjects :
- medicine.medical_specialty
Chemotherapy
business.industry
medicine.medical_treatment
digestive, oral, and skin physiology
Treatment options
Sarcomatosis
Hematology
Disease
medicine.disease
digestive system diseases
Palliative surgery
Surgery
Oncology
Pediatrics, Perinatology and Child Health
Round cell
Medicine
Hyperthermic intraperitoneal chemotherapy
Sarcoma
Radiology
business
Subjects
Details
- ISSN :
- 15455009
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Pediatric Blood & Cancer
- Accession number :
- edsair.doi...........6e586721d07c086b881cba6aebeb784b