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Correlation of observed-to-expected total fetal lung volume with intrathoracic organ herniation on magnetic resonance imaging in fetuses with isolated left-sided congenital diaphragmatic hernia

Authors :
Jan Deprest
Filip Claus
Jute Richter
Maissa Rayyan
Inga Sandaite
Philip DeKoninck
Katika Nawapun
Mary Patrice Eastwood
Source :
Ultrasound in Obstetrics & Gynecology. 46:162-167
Publication Year :
2015
Publisher :
Wiley, 2015.

Abstract

Objectives To assess using fetal magnetic resonance imaging (MRI) the relationship between the position of the stomach as well as the volume of herniation of organs into the thorax, and the observed-to-expected total fetal lung volume (o/e-TFLV), as a measure of pulmonary hypoplasia, in fetuses with isolated left-sided congenital diaphragmatic hernia (LCDH). Methods This was a single-center retrospective study using archived MR images from fetuses > 20 weeks' gestation evaluated for isolated LCDH over an 11-year period between July 2002 and September 2013. We retrieved data on the gestational age at MRI, o/e-TFLV and liver position. Images were also reviewed by a single operator to determine retrospectively the position of the stomach as well as the proportion of the total thorax volume occupied by the herniated fetal liver, stomach and other viscera. Following confirmation of reproducibility, we assessed the correlation of intrathoracic organ volumes and stomach position with o/e-TFLV. Results The study included 205 fetuses which underwent a total of 259 MR examinations. The reproducibility of organ volume measurements was excellent (intraclass correlation coefficient range, 0.928–0.997). The average time spent to obtain intrathoracic organ volumes ranged from 2.28 to 5.13 min. Of all herniated organ-to-thoracic volume ratios, the liver-to-thoracic volume ratio had the strongest correlation with o/e-TFLV (ρ = −0.429, P

Details

ISSN :
09607692
Volume :
46
Database :
OpenAIRE
Journal :
Ultrasound in Obstetrics & Gynecology
Accession number :
edsair.doi...........6e4da0eab6ce6ff46a180fae9b1fe48e
Full Text :
https://doi.org/10.1002/uog.14701