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Combinatorial inhibition of Polo-like kinase 1 (PLK1) and microtubule dynamics to induce synthetic lethality in ovarian cancer cells with CCNE1-amplification
- Source :
- Journal of Clinical Oncology. 36:e17537-e17537
- Publication Year :
- 2018
- Publisher :
- American Society of Clinical Oncology (ASCO), 2018.
-
Abstract
- e17537Background: High-grade serous ovarian cancer (HGSOC) (70%) has poor prognosis. Drivers of HGSOC are p53 mutations, homologous recombination deficiencies and CCNE1-amplification. Olaparib chan...
- Subjects :
- 0301 basic medicine
Cancer Research
endocrine system diseases
Microtubule dynamics
business.industry
Synthetic lethality
Polo-like kinase
PLK1
female genital diseases and pregnancy complications
Olaparib
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
0302 clinical medicine
Oncology
chemistry
CCNE1 Amplification
030220 oncology & carcinogenesis
Cancer research
Ovarian cancer cells
Medicine
business
Homologous recombination
Subjects
Details
- ISSN :
- 15277755 and 0732183X
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Oncology
- Accession number :
- edsair.doi...........6e4d748c0a62cbfa3ae821a177b3049b
- Full Text :
- https://doi.org/10.1200/jco.2018.36.15_suppl.e17537