Asymmetric Addition of Diethylzinc to Ketones promoted by Tartaric Acid Derivatives

Authors :: Ailing Hui
Zhiyong Wang
Jintang Zhang
Source :: Synthetic Communications. 38:2374-2384
Publication Year :: 2008
Publisher :: Informa UK Limited, 2008.
Abstract: The preparation of new sulfonamide ligands derived from L-tartaric acid and camphor sulfonyl chloride are described. The employment in the titanium tetraisopropoxide-promoted enantioselective addition of diethylzinc to ketones has been studied. The best enantiomeric excess is up to 99% with 7 mol% catalyst loading at room temperature.

Subjects :: chemistry.chemical_classification
chemistry.chemical_compound
Camphor
Ketone
Chemistry
Organic Chemistry
Enantioselective synthesis
Tartaric acid
Organic chemistry
Diethylzinc
Enantiomeric excess
Catalysis
Sulfonamide

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