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Remission of diabetic nephropathy in type 2 diabetic Asian population: role of tight glucose and blood pressure control

Authors :
Ming-Chia Hsieh
Tzu-Jung Cho
Shih-Te Tu
Jung-Fu Chen
Hung-Chun Chen
Yi-Ting Hsieh
Shi-Dou Lin
Source :
European Journal of Clinical Investigation. 41:870-878
Publication Year :
2011
Publisher :
Wiley, 2011.

Abstract

Eur J Clin Invest 2011; 41 (8): 870–878 Abstract Background Asian has higher prevalence of diabetic nephropathy (DN) and end-stage renal disease when compared to Caucasian. No study to date has evaluated whether multifactorial intervention was associated with remission of microalbuminuria in type 2 diabetic Asian population. We evaluated the effect of tightly controlling multiple factors on the remission of DN in type 2 diabetic Chinese with microalbuminuria. Materials and methods A longitudinal cohort study was collected 587 type 2 diabetic patients with microalbuminuria. Cohort members received intensified treatment to meet the following ADA recommended goals: HbA1c 40 mg dL−1 for men and > 50 mg dL−1 for women. Remission of microalbuminuria was defined as shift of albumin–creatinine ratio from mircoalbuminuria to normoalbuminuria. Results During the 4·5-year period, 210 (35·8%) patients achieved remission to normoalbuminuria. A significant association was found between the achievement of ADA goals, including HbA1c

Details

ISSN :
00142972
Volume :
41
Database :
OpenAIRE
Journal :
European Journal of Clinical Investigation
Accession number :
edsair.doi...........6dad92de0fec436941a9837e07a4d309
Full Text :
https://doi.org/10.1111/j.1365-2362.2011.02479.x