Back to Search
Start Over
Recurrence ofHelicobacter pyloriinfection and the affecting factors: A follow-up study
- Source :
- Journal of Digestive Diseases. 18:47-55
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Objective Recurrence of Helicobacter pylori (H. pylori) infection weakens the protective effect and long-term prognosis of eradication. With the widespread therapies, decreasing prevalence of H. pylori infection and improvement in living conditions, the recurrence of H. pylori infection may present with new features. We conducted this prospective, large-scale, multicenter follow-up study to determine the recurrence rate of H. pylori infection and its affecting factors. Methods A total of 827 patients receiving successful H. pylori eradication in our previous randomized controlled trial were enrolled. 13 C-urea breath test (UBT) was repeated one year after the eradication therapy to determine its recurrence. Moreover, a questionnaire survey was performed to explore the potential factors affecting the recurrence. Results A total of 743 patients completed 13C-UBT (follow-up rate 89.8%), and the result was positive in 13 patients one year after eradication therapy, with an annual recurrence rate of 1.75% (95% confidence interval [CI] 0.81–2.69%). Six hundred and ninety-two patients (13 with recurrence and 679 without recurrence) returned their questionnaires, with a response rate of >80%. Multivariate analysis revealed that peptic ulcer (odds ratio [OR] 3.385, 95% CI 1.016–11.274), close contact with individuals having H. pylori infection (OR 4.231, 95% CI 1.201–14.911), and hospitalization (OR 9.302, 95% CI 2.441–35.440) were independent risk factors of H. pylori infection recurrence. Conclusions The recurrence of H. pylori infection one year after eradication therapy is low in urban population of China. Peptic ulcer, contact history with individuals having H. pylori infection and hospitalization are risk factors.
- Subjects :
- medicine.medical_specialty
Multivariate analysis
Population
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
medicine
030212 general & internal medicine
education
Breath test
Response rate (survey)
education.field_of_study
medicine.diagnostic_test
biology
business.industry
Gastroenterology
Odds ratio
Helicobacter pylori
biology.organism_classification
Confidence interval
Surgery
030211 gastroenterology & hepatology
business
Subjects
Details
- ISSN :
- 17512972
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Journal of Digestive Diseases
- Accession number :
- edsair.doi...........6d7dd627a88477ccf4c90fe07939d3d2