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THE ETIOLOGY OF FEBRILE ILLNESS IN ADULTS PRESENTING TO PATAN HOSPITAL IN KATHMANDU, NEPAL
- Source :
- The American Journal of Tropical Medicine and Hygiene. 70:670-675
- Publication Year :
- 2004
- Publisher :
- American Society of Tropical Medicine and Hygiene, 2004.
-
Abstract
- In Nepal, many infections remain poorly characterized, partly due to limited diagnostic facilities. We studied consecutive febrile adults presenting to a general hospital in Kathmandu, Nepal. Of the 876 patients enrolled, enteric fever and pneumonia were the most common clinical diagnoses. Putative pathogens were identified in 323 (37%) patients, the most common being Salmonella enterica serotype Typhi and S. enterica serotype Paratyphi A (117), Rickettsia typhi (97), Streptococcus pneumoniae (53), Leptospira spp. (36), and Orientia tsutsugamushi (28). Approximately half of the Salmonella isolates were resistant to nalidixic acid. No clinical predictors were identified to reliably distinguish between the different infections. These findings confirm the heavy burden of enteric fever and pneumonia in Kathmandu, and highlight the importance of murine typhus, scrub typhus, and leptospirosis. Given the lack of reliable clinical predictors, the development of cheap and accurate diagnostic tests are likely to be of great clinical utility in this setting.
- Subjects :
- medicine.medical_specialty
Orientia tsutsugamushi
biology
business.industry
Salmonella paratyphi A
Scrub typhus
bacterial infections and mycoses
Salmonella typhi
biology.organism_classification
medicine.disease
Murine typhus
Leptospirosis
Pneumonia
Infectious Diseases
Virology
Internal medicine
Rickettsia typhi
Immunology
medicine
bacteria
Parasitology
business
Subjects
Details
- ISSN :
- 14761645 and 00029637
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- The American Journal of Tropical Medicine and Hygiene
- Accession number :
- edsair.doi...........6d7821557884bb23fcc9c3ceaf001d4d