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Synthesis of highly-functionalised pyridines via hetero-Diels–Alder methodology: reaction of 3-siloxy-1-aza-1,3-butadienes with electron deficient acetylenes
- Source :
- Tetrahedron. 62:5454-5463
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- The hetero-Diels–Alder reaction between 1-aza-3-siloxy-1,3-butadienes and electron deficient acetylenes is described. The reactivity of a range of α,β-unsaturated oximes and hydrazones is assessed in the synthesis of tri- and tetra-substituted pyridines bearing an oxygen functionality at C-3. Microwave irradiation has been employed to decrease the extended reaction times and increase the poor yields often associated with this reaction.
Details
- ISSN :
- 00404020
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Tetrahedron
- Accession number :
- edsair.doi...........6c934fd0d956777d2e94f48ddb95329c