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Dearomative [4 + 2] annulations between 3-nitroindoles and enals through oxidative N-heterocyclic carbene catalysis
- Source :
- Organic Chemistry Frontiers. 7:3862-3867
- Publication Year :
- 2020
- Publisher :
- Royal Society of Chemistry (RSC), 2020.
-
Abstract
- Hydrocarbazolone and its derivatives are attractive organic molecules, which have been widely applied in the synthesis of natural products and pharmaceuticals. Herein, we describe a novel intermolecular dearomative [4 + 2] annulation of 3-nitroindoles and enals under oxidative N-heterocyclic carbene catalysis. With this organocatalytic strategy, a variety of dearomatised hydrocarbazolone products were obtained in high yields. This protocol was also suitable for the oxidative cyclisation of 2-nitrobenzothiophenes with enals, thereby affording a collection of 4-hydroxyldibenothiophenes.
Details
- ISSN :
- 20524129
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Organic Chemistry Frontiers
- Accession number :
- edsair.doi...........6c8662d64c6fc43f655cdac747282e9e