Mechanical characteristics of composites of polylactide and nanosized calcium phosphates formed in supercritical carbon dioxide

Composite materials for biomedical applications based on polylactide, a bioresorbable polymer, and nanosized calcium phosphate (hydroxyapatite) were produced using supercritical (SC) carbon dioxide. For composites with different polymer-to-mineral ratios, the bending stress-strain diagrams were investigated. The elasticity moduli of composites obtained in SC-CO2 from powdered bioresorbable polymer and bioactive nanoceramics ranged elastic modulus of natural bone. Experiments on adhesion of human embryonic fibroblasts demonstrated the suitability of generated samples for use in bone tissue scaffold engineering and regenerative medicine.