The isolation and in vivo Potent Antitumor activity of clerodane diterpenoid from the oleoresin of the brazilian medicinal plant, copaifera langsdorfi desfon

An extremely potent antitumor neo -clerodane diterpene was isolated from the oleoresin of the Brazilian medicinal plant, Copaifera langsdorfii Desfon. This compound was identified as (-)-kolavenol 1 . The antitumor effect of 1 against IMC carcinomas as determined from the increase in lifespan (I.L.S.) in mice was twice that of 5-FU. The structure elucidation and the antitumor activity of the other related compounds 2 ∼ 6 in this oleoresin were also described.