FRI0594-HPR Pain, function and quality of life in different degrees of knee osteoarthritis: is there a difference?

Background Osteoarthritis (OA) is a prevalent disease associated with significant morbidity and is one of most common causes of pain, functional limitations and dependence, possibly compromising the quality of life. Objectives To compare pain, function and quality of life in different degrees of knee OA. Methods The study included 100 patients of both sexes, aged between 50 and 75 years and grade 2, 3 or 4 of OA by Kellgren and Lawrence’s classification 1 . The patients were divided into three groups according to the degree of knee OA: Group G2 - patients with grade 2 (n = 35), group G3 - patients with grade 3 (n = 40) and G4 group - patients with grade 4 (n = 25). Pain intensity was assessed by visual analog scale (VAS), quality of life by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and functionality by the Lequesne Functional Questionnaire. Statistical analysis was performed using one way ANOVA with Holm-Sidak method for intergroup analysis and the Kruskal-Wallis for non-parametric values. The significance level was α=0.05. Results The age and body mass index were similar between groups. For the WOMAC function subscale, WOMAC total score and LEQUESNE there was a significant difference between G2 and G3 (p Image/graph Conclusions Patients with grade 3 of knee osteoarthritis had a poorer quality of life and function compared to patients with grade 2 and 4. There was no significant difference for pain and for WOMAC pain and stiffness subscales in the three groups. References Kellgren JH, Lawrence JS. Radiological assessment of osteoarthritis. Ann Rheum Dis. 1957;16(4):494-501. Acknowledgements Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP Disclosure of Interest None Declared