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Synthesis ofβ-Hydroxy Nitriles via Indium-Induced Coupling of Bromoacetonitrile with Carbonyl Compounds
- Source :
- Bulletin of the Chemical Society of Japan. 67:1126-1129
- Publication Year :
- 1994
- Publisher :
- The Chemical Society of Japan, 1994.
-
Abstract
- The organoindium reagent, derived from indium metal and bromoacetonitrile, reacted with carbonyl compounds in the presence of chlorotrimethylsilane to give, after hydrolysis, β-hydroxy nitriles. The coupling proceeded with high chemoselectivity, though the diastereoselectivity was low.
Details
- ISSN :
- 13480634 and 00092673
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Bulletin of the Chemical Society of Japan
- Accession number :
- edsair.doi...........6a787cef8fbf28f0b477d0ed1babeb98
- Full Text :
- https://doi.org/10.1246/bcsj.67.1126