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ChemInform Abstract: Further Studies on the Synthesis of Quinazolines from 2- Fluorobenzonitriles
- Source :
- ChemInform. 23
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Recently, we reported that appropriately substituted 2-fluorobenzonitriles undergo cyclization with guanidine carbonate to afford 2,4-diaminoquinazolines usually in good to excellent yield. This paper describes the preparation of a variety of new 2,4-diaminoquinazolines substituted at positions five or seven. In addition, the reactions of selected 2-fluorobenzonitriles with formamidine acetate or acetamidine acetate were examined. The results obtained demonstrate that the analogous 4-amino- and 2-methyl-4-aminoquinazolines can be prepared by this approach but that the yields are considerably lower than when guanidine carbonate is employed as the cyclization reagent.
Details
- ISSN :
- 09317597
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........6a10d60fd6e10cf38fcf36403331346d