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Synthesis and properties of cyanomethyl derivatives of imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine, and imidazo[2,1-b]thiazole

Authors :
N. V. Kovalenko
Yu. M. Volovenko
G. P. Kutrov
Source :
Russian Journal of Organic Chemistry. 44:257-262
Publication Year :
2008
Publisher :
Pleiades Publishing Ltd, 2008.

Abstract

2-Cyanomethyl derivatives were obtained of imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine, and imidazo[2,1-b]thiazole, and their reactivity was investigated by an example of imidazo[1,2-a]pyridine: It was subjected to nitration, bromination, azo coupling and nitrosation. Acylation of the methylene group effected by amino acids esters with a subsequent addition of the amino group to the cyano group resulted in the formation of 5-amino-4-imidazo[1,2-a]-pyridin-2-yl-1-phenyl-1,2-dihydro-3H-pyrrol-3-one and 2-amino-1-ethyl-3-imidazol[1,2-a]pyridin-2-yl-4(1H)-quinolinone.

Details

ISSN :
16083393 and 10704280
Volume :
44
Database :
OpenAIRE
Journal :
Russian Journal of Organic Chemistry
Accession number :
edsair.doi...........6a10b26f77901e79c46c5b896a9067a9
Full Text :
https://doi.org/10.1134/s1070428008020127