Inhaled Nitric Oxide Increases Markers of Oxidant Stress in the Serum of Term Infants with Cardiorespiratory Failure ♦ 1767

Introduction: In several clinical trials in term infants with respiratory failure, inhaled nitric oxide (INO) has been shown to acutely increase oxygenation and significantly decrease mortality and/or need for ECMO. The long term effects of INO remain largely unknown. Both NO and its metabolites react to form cytotoxic species which may be involved in the development of chronic lung disease. The purpose of this investigation was to determine whether there is increased oxidant stress in the serum of infants receiving INO when compared to normal controls and infants exposed to hyperoxia.