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Saccharide Recognition and Helix Formation in Water with an Amphiphilic Pyridine-Phenol Alternating Oligomer
- Source :
- European Journal of Organic Chemistry. 2017:6975-6979
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- An amphiphilic pyridine-phenol alternating oligomer, in which oligo(ethylene glycol) chains are attached at the 4-positions of the pyridine and the phenol rings, was synthesized as a helical host to realize saccharide recognition in water. This oligomer was soluble not only in less-polar solvents but also in water at room temperature. Circular dichroism investigations revealed that the oligomer could recognize several kinds of saccharides and their derivatives including glycodrugs to form chiral higher-order structures in water. Especially, the oligomer showed high affinity for D-glucosamine, and their association constants were over 10³ M¯¹.
- Subjects :
- Circular dichroism
010405 organic chemistry
Chemistry
Hydrogen bond
Organic Chemistry
Supramolecular chemistry
010402 general chemistry
01 natural sciences
Oligomer
0104 chemical sciences
chemistry.chemical_compound
Molecular recognition
Amphiphile
Helix
Polymer chemistry
Physical and Theoretical Chemistry
Ethylene glycol
Subjects
Details
- ISSN :
- 1434193X
- Volume :
- 2017
- Database :
- OpenAIRE
- Journal :
- European Journal of Organic Chemistry
- Accession number :
- edsair.doi...........69abe26d5f923590bbf056943b37ba0a