Two NewGγ Chain Variants: Hb F-Saint-Etienne [Gγ79(EF3)Asp→His] and Hb F-Lyon [Gγ97(FG4)His→Arg]

Two new fetal hemoglobin (Hb F) variants affecting the Gγ chain are reported: Hb F-Saint-Etienne [Gγ79(EF3)Asp→His] and Hb F-Lyon [Gγ97(FG4)His→Arg]. These new Hb variants were found during a neonatal screening for hemoglobinopathies but characterized a few months later by our reference laboratory. The corresponding mutations are located on the external part of the Hb molecule and seem to be clinically silent.