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Differentiating syndrome of inappropriate ADH, reset osmostat, cerebral/renal salt wasting using fractional urate excretion
- Source :
- Journal of Pediatric Endocrinology and Metabolism. 34:137-140
- Publication Year :
- 2020
- Publisher :
- Walter de Gruyter GmbH, 2020.
-
Abstract
- Objectives Clinical and laboratory data of reset osmostat (RO) and cerebral/renal salt wasting (C/RSW) mimic syndrome of inappropriate antidiuretic hormone (SIADH) and can pose diagnostic challenges because of significant overlapping between clinical and laboratory findings. Failure to correctly diagnose hyponatremia may result in increased mortality risk, longer hospital stay, and is cost-effective. We aim to illustrate clinical and laboratory similarities and difference among patients with hyponatremic disorders and discuss the diagnostic value of factional uprate excretion (FEurate) to differentiate SIADH from RO and C/RSW. Case presentations We report the use of FEurate in the evaluation of three patients with hyponatremia and elevated urine osmolality in the absence of edema or clinical evidence of dehydration to differentiate SIADH from RO and C/RSW. Conclusions Measurement of FEurate may offset in part the diagnostic confusion imparted by the diagnoses of SIADH, RO, and C/RSW.
- Subjects :
- medicine.medical_specialty
business.industry
Endocrinology, Diabetes and Metabolism
030232 urology & nephrology
Osmostat
medicine.disease
Gastroenterology
Excretion
03 medical and health sciences
Renal salt wasting
0302 clinical medicine
Endocrinology
Internal medicine
Edema
Pediatrics, Perinatology and Child Health
medicine
Urine osmolality
medicine.symptom
Hyponatremia
Urate excretion
business
030217 neurology & neurosurgery
Antidiuretic
Subjects
Details
- ISSN :
- 21910251 and 0334018X
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Journal of Pediatric Endocrinology and Metabolism
- Accession number :
- edsair.doi...........69489334218479f960e20fdc01ec416b