Asymmetric synthesis of diarylmethylamines: preparation of selective opioid delta receptor ligands

Authors :: Carl Berthelette
Daniel Delorme
Edward Roberts
Rico Lavoie
Source :: Tetrahedron: Asymmetry. 9:3963-3966
Publication Year :: 1998
Publisher :: Elsevier BV, 1998.
Abstract: Two different methods were used for the construction of optically active diarylmethylamines. Diastereoselective alkylation on an aldimine/oxazolidine 2a / 2b derived from ( R )/( S )-phenylglycinol or enantioselective reduction of 4-[η 6 -chromium tricarbonylbenzoyl] bromobenzene using chiral oxazoborolidine followed by amine introduction to furnish optically active diarylmethylamines.

Subjects :: chemistry.chemical_classification
Aldimine
Oxazolidine
Chemistry
Stereochemistry
Organic Chemistry
Enantioselective synthesis
chemistry.chemical_element
Alkylation
Catalysis
Inorganic Chemistry
δ-opioid receptor
chemistry.chemical_compound
Chromium
Bromobenzene
Amine gas treating
Physical and Theoretical Chemistry

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