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Determination of flavonoids from Cirsium japonicum var. maackii and their inhibitory activities against aldose reductase
- Source :
- Applied Biological Chemistry. 60:487-496
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- The therapeutic activities of flavonoids from natural plant sources were investigated. The ethanol extracts from the aerial parts of Cirsium japonicum var. maackii (CJM) were tested for aldose reductase inhibition (ARI). Additionally, stepwise polarity fractions and flavonoids from CJM were evaluated for ARI. The ethyl acetate (EtOAc) fraction from CJM showed significant inhibitory effects. The compounds in the EtOAc fraction were identified as the flavonoids-cirsimaritin (1), hispidulin (2), and cirsimarin (3). Based on an ARI assay, the EtOAc fraction and hispidulin (2) exhibited good AR inhibitory activity (IC50 values of 0.21 μg/mL and 0.77 μM, respectively). An HPLC quantitative analysis of different parts of CJM showed that the aerial part collected in the spring season (CJL1) contains the highest total flavonoid content. These results serve as a basis for maximizing the flavonoid yield and for the efficient usage of various parts of CJM. Our results also suggest that CJM could be a useful ARI material for the treatment of various diabetic complications.
- Subjects :
- 0301 basic medicine
chemistry.chemical_classification
Aldose reductase
Traditional medicine
fungi
Organic Chemistry
Flavonoid
Ethyl acetate
food and beverages
Inhibitory postsynaptic potential
01 natural sciences
High-performance liquid chromatography
General Biochemistry, Genetics and Molecular Biology
0104 chemical sciences
010404 medicinal & biomolecular chemistry
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
Biochemistry
chemistry
Hispidulin
Cirsium japonicum
Quantitative analysis (chemistry)
Subjects
Details
- ISSN :
- 24680842 and 24680834
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Applied Biological Chemistry
- Accession number :
- edsair.doi...........68e1f3d648372a9ae048c9a99d5d9a07