MARKERS OF DAMAGE TO NERVOUS TISSUE IN LIQUOR PATIENTS WITH VARIOUS FORMS OF NEUROSYPHILIS

The purpose: to study the features of markers of lesion of nervous tissue and cytokines in patients with various forms of neurosyphilis. Material and methods. The complex clinical examination of patients with syphilis was carried out in the venereological department of the Clinical dermatovenerologic dispensary in Omsk in the period from 2015 to 2017, in order to identify signs of damage to the nervous system. Results: the presence of regularities and features in the deviation of the immune status in neurosyphilis was found. Conclusion. Analysis of the immunological changes in the cerebrospinal fluid showed that the level of interleukin 12p40 is significantly higher in the cerebrospinal fluid of patients with neurosyphilis, while the maximum values of these indicators are in patients with manifest forms of pathology. In patients with neurosyphilis, the concentration of glial fibrillar acidic protein in CSF was statistically significantly increased then in comparison group.