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P25 Hydrogen sulfide attenuates angiotensin II-induced hypertension, proteinuria and renal damage

Authors :
Harry van Goor
Andreas Pasch
Anne M. Koning
Gerjan Navis
Jan-Luuk Hillebrands
Henri G. D. Leuvenink
Eelke M. Bos
Matthias Bachtler
Arjan J. Kwakernaak
Else van den Berg
Anne-Roos S. Frenay
Pauline M. Snijder
Source :
Nitric Oxide. 39:S23-S24
Publication Year :
2014
Publisher :
Elsevier BV, 2014.

Abstract

Hypertension and proteinuria are important mediators of renal damage. Since H2S has vasodilatory, anti-inflammatory and antioxidant properties, we investigated its effects in Angiotensin II (Ang II)-induced hypertensive renal disease in rats. Treatment with H2S donors (NaHS or sodium thiosulfate (STS)) during three weeks of Ang II infusion reduced hypertension by 22% and 18% resp (p

Details

ISSN :
10898603
Volume :
39
Database :
OpenAIRE
Journal :
Nitric Oxide
Accession number :
edsair.doi...........68d755bab16fcdf5ecd5ae28406a0499