ChemInform Abstract: Synthesis of Tetrahydrofurocarbazolones via Intramolecular Diels-Alder Reactions

10-Aryl-3a,4,10,10a-tetrahydrofuro[3,4-b]carbazol-1-ones were synthesized by an intramolecular Diels-Alder reaction. Exo / endo product ratios were found to be sensitive to both solvent and temperature. The synthesis of iso elliptitoxin 2 , a hybrid molecule of ellipticine and 4'-demethylpodophyllotoxin, is presented.