Impact of age and sex on chemotherapy (CTx) efficacy, toxicity and survival in early oesophagogastric (OG) cancer: A pooled analysis of 3265 patients from four large randomised trials (OE02, OE05, MAGIC & ST03)

Authors :: Heike I. Grabsch
David Cunningham
Nicholas P. West
Ruth E Langley
William H. Allum
Joyce Thompson
Avani Athauda
Naureen Starling
Erica Beaumont
Susan Pritchard
Fareeda Y. Coxon
Matthew Nankivell
Stephen Falk
Adrian Crellin
Suzanne Darby
Wasat Mansoor
Rupert Langer
D Alderson
Sebastian Cummins
Ian Chau
Source :: Journal of Clinical Oncology. 37:4022-4022
Publication Year :: 2019
Publisher :: American Society of Clinical Oncology (ASCO), 2019.
Abstract: 4022 Background: No large scale randomised data exists evaluating the impact of age and sex in patients (pts) undergoing potentially curative surgery and CTx for OG cancer. However, differences in age and sex may be contributing factors to variability in CTx dose-response and toxicity which could also impact survival. Methods: Data from four prospective randomised controlled trials were pooled using a two-stage meta-analysis. For survival data, hazard ratios were calculated for pts

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