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Algorithms for the determination of unacceptable HLA antigen mismatches in kidney transplant recipients
- Source :
- Tissue Antigens. 82:83-92
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- One of the major tasks of human leukocyte antigen (HLA) laboratories is the pretransplant determination of unacceptable HLA antigen mismatches (UAM) in organ transplant recipients. HLA antigen specificities are determined against which the patient has circulating alloantibodies that are expected to harm the transplanted organ. Using the information on UAM, negative crossmatch (XM) prediction or 'virtual XM' is possible when a potential donor's complete HLA typing is available. Before the introduction of solid-phase antibody detection assays, UAM were determined using the complement-dependent cytotoxicity methodology. After the introduction of the single antigen bead technique, however, various UAM determination algorithms have emerged. In this report, six different laboratories worldwide present how they determine UAM in their collective of kidney transplant recipients in the pretransplant phase and proceed thereafter to transplantation.
- Subjects :
- medicine.medical_specialty
business.industry
Immunology
General Medicine
Human leukocyte antigen
medicine.disease
Biochemistry
Kidney transplant
Organ transplantation
Transplantation
Genetics
medicine
Immunology and Allergy
Potential donor
Single antigen bead
business
Algorithm
Kidney transplantation
Antibody detection
Subjects
Details
- ISSN :
- 00012815
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- Tissue Antigens
- Accession number :
- edsair.doi...........685314f82fd4e0a67cf9c0b9fa7f5779