2201 Peri-operative chemotherapy ± bevacizumab for resectable gastro-oesophageal adenocarcinoma: Results from the UK Medical Research Council randomised ST03 trial (ISRCTN 46020948)

surgery occurred in 3(5.6%) and 4(7.4%) patients in the CT group versus 4(7.8%) and 3(5.9%) patients in the CRT group. Conclusions: Part 1 of the TOPGEAR trial demonstrates preoperative CRT to be safe and feasible. With IDSMC recommendation the trial has proceeded to Part 2 where overall survival will be the primary end point. Current accrual is 170 patients recruited from 55 active sites. No conflict of interest.