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Effects of Menstrual Cycle and Female Sex Steroids on Ethanol Pharmacokinetics
Effects of Menstrual Cycle and Female Sex Steroids on Ethanol Pharmacokinetics
- Source :
- Alcoholism: Clinical and Experimental Research. 23:250-255
- Publication Year :
- 1999
- Publisher :
- Wiley, 1999.
-
Abstract
- This study investigated the influence of menstrual cycle and female sex steroid levels on ethanol pharmacokinetics. In a within-subjects design, 24 female volunteers each consumed 0.67 g kg -1 ethanol during the menstrual and luteal phases of their menstrual cycle. On each test day, we collected blood samples before ethanol administration to determine estradiol (E 2 ) and progesterone (P) levels and to confirm ovulation. We took 20 or more postdrink breath ethanol concentration readings and examined pharmacokinetic differences between the two phases, using classical pharmacokinetic measures, as well as Michaelis-Menten measures. Despite highly significant differences in measured E 2 as well as P levels on the 2 test days, and despite excluding subjects with anovulatory cycles from the analysis, there were no significant differences between menstrual and luteal phases for any of the pharmacokinetic variables. We found no correlation between E 2 or P levels and any of the pharmacokinetic measures. In summary, we found no evidence that the tested menstrual cycle phases or varying E 2 and progesterone levels significantly influence ethanol pharmacokinetics. Because previous studies about the topic have used few subjects and revealed controversial results, we consider our negative findings based on 24 subjects meaningful.
- Subjects :
- medicine.medical_specialty
medicine.drug_class
media_common.quotation_subject
Medicine (miscellaneous)
Biology
Luteal phase
Toxicology
Psychiatry and Mental health
Endocrinology
Pharmacokinetics
Estrogen
Oral administration
Internal medicine
medicine
Toxicokinetics
Ethanol metabolism
Ovulation
Menstrual cycle
media_common
Subjects
Details
- ISSN :
- 15300277 and 01456008
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Alcoholism: Clinical and Experimental Research
- Accession number :
- edsair.doi...........67f1c960a7a488a9492b0ae9ecd18eef
- Full Text :
- https://doi.org/10.1111/j.1530-0277.1999.tb04107.x