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[Untitled]
- Source :
- Arthritis Research. 4:281
- Publication Year :
- 2002
- Publisher :
- Springer Science and Business Media LLC, 2002.
-
Abstract
- Bone-resorbing osteoclasts are formed from hemopoietic cells of the monocyte–macrophage lineage under the control of bone-forming osteoblasts. We have cloned an osteoblast-derived factor essential for osteoclastogenesis, the receptor activator of NF-κB ligand (RANKL). Synovial fibroblasts and activated T lymphocytes from patients with rheumatoid arthritis also express RANKL, which appears to trigger bone destruction in rheumatoid arthritis as well. Recent studies have shown that T lymphocytes produce cytokines other than RANKL such as IL-17, granulocyte–macrophage colony-stimulating factor and IFN-γ, which have powerful regulatory effects on osteoclastogenesis. The possible roles of RANKL and other cytokines produced by T lymphocytes in bone destruction are described.
- Subjects :
- musculoskeletal diseases
biology
business.industry
Arthritis
medicine.disease
Bone resorption
Haematopoiesis
Granulocyte macrophage colony-stimulating factor
medicine.anatomical_structure
Rheumatology
RANKL
Rheumatoid arthritis
Immunology
medicine
biology.protein
Interleukin 17
Synovial membrane
business
medicine.drug
Subjects
Details
- ISSN :
- 14659905
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Arthritis Research
- Accession number :
- edsair.doi...........679db202650b53b2e5c26c5a95abcb03