Palladium-CatalyzedN-Demethylation/N-Acylation of Some Morphine and Tropane Alkaloids

Authors :: Robert J. Carroll
Hannes Leisch
Tomas Hudlicky
Eric W. Scocchera
D. Phillip Cox
Source :: Advanced Synthesis & Catalysis. 350:2984-2992
Publication Year :: 2008
Publisher :: Wiley, 2008.
Abstract: Hydrocodone was converted to various N-acyl derivatives via a one-pot N-demethylation/N-acylation protocol catalyzed by palladium(II). The procedure has also been successfully applied to several N-methyltropane alkaloids. A plausible mechanism is suggested.

Subjects :: inorganic chemicals
Stereochemistry
chemistry.chemical_element
Tropane
General Chemistry
complex mixtures
Catalysis
Acylation
chemistry.chemical_compound
chemistry
N acylation
Hydrocodone
Morphine
medicine
lipids (amino acids, peptides, and proteins)
Demethylation
medicine.drug
Palladium

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