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SARS-CoV-2 BA.4 infection triggers more cross-reactive neutralizing antibodies than BA.1
- Publication Year :
- 2022
- Publisher :
- Cold Spring Harbor Laboratory, 2022.
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Abstract
- SARS-CoV-2 variants of concern (VOCs) differentially trigger neutralizing antibodies with variable cross-neutralizing capacity. Here we show that unlike SARS-CoV-2 Omicron BA.1, which triggered neutralizing antibodies with limited cross-reactivity, BA.4/5 infection triggers highly cross-reactive neutralizing antibodies. Cross-reactivity was observed both in the absence of prior vaccination and also in breakthrough infections following vaccination. This suggests that next-generation vaccines incorporating BA.4, which is spreading globally, might result in enhanced neutralization breadth.
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........674e29a39a86baa8fe9ffa7f6903a1ea