Mo1971 The Prevalence of Eosinophilic Esophagitis in Japanese Children and Adolescents

Background and Aims: The epidemiology of gastrointestinal disorder is poorly described among Japanese children. Our aim is to clarify the trend of GI diseases' prevalence at Pediatric GI practice in Japan over the last decade. Methods: Children and adolescents with GI symptoms from 2001 to 2011 were identified by endoscopic databases at Shinshu University Hospital and Showa Inan General Hospital. Procedures were performed by pediatric GIs and routine biopsies were taken from every landmark. The prevalence of newly diagnosed GI disorders, especially Helicobacter pylori related disorders, eosinophilic gastrointestinal diseases (EGIDs) and inflammatory bowel disorder (IBD), are evaluated. Results: In total, 772 procedures (534 esophagogastroduodenoscopy[EGD] and 237 colonoscopy[CS]) were performed for 552 Japanese children and adolescents (54% female, average 11.47±4.57 year). Of 552 patients, 93 (18%) had H. pylori infection, and 27 (29%) of H. pylori positive subjects had peptic ulcer (22 duodenal ulcer and 5 gastric ulcer). Twenty-two patients (4%) were diagnosed as EGIDs (11 eosinophilic gastroenteritis, 11 eosinophilic colitis and no patient of eosinophilic esophagitis despite routine biopsies from esophagus). Twelve patients were diagnosed as IBD (10 Ulcerative colitis and 2 Crohn's disease). The trend of each disorder was shown in Figure 1. Conclusion: EGIDs have increased dramatically in a few years. On the other hand, H. pyori infection decreased almost one-fifth over 10 years in Japanese children.