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Persistence of group B Streptococcus vaginal colonization and prevalence of hypervirulent CC-17 clone correlate with the country of birth: a prospective 3-month follow-up cohort study

Authors :
Amiel Falloukh
Olivia Anselem
Caroline Joubrel
Valérie Marcou
Laurent Mandelbrot
Pierre-Yves Ancel
Claire Poyart
Amandine Frigo
Fatma Magdoud El Alaoui
Céline Plainvert
Asmaa Tazi
François Goffinet
Pierre Henri Jarreau
Source :
European Journal of Clinical Microbiology & Infectious Diseases. 40:133-140
Publication Year :
2020
Publisher :
Springer Science and Business Media LLC, 2020.

Abstract

To identify factors associated with vaginal colonization and persistence by group B Streptococcus (GBS) and by the hypervirulent neonatal CC-17 clone in late pregnancy and after delivery, a multicentre prospective observational cohort with 3-month follow-up was established in two university hospitals, Paris area, France. Pregnant women were recruited when antenatal screening for GBS vaginal colonization at 34–38 weeks of gestational age was positive. Vaginal samples were analysed by conventional culture methods at antenatal screening, delivery, and 21 and 60 days following delivery. Identification of the hypervirulent neonatal GBS CC-17 was performed. Colonization was defined as persistent when all vaginal samples were positive for GBS. A total of 754 women were included. GBS vaginal colonization was persistent in 63% of the cases (95% CI 59%–67%). Persistent colonization was more likely in women born in Sub-Saharan Africa compared with women born in France (OR = 1.88, 95% CI 1.05–3.52), and GBS CC-17 was overrepresented in women born in Sub-Saharan Africa (OR = 2.09, 95% CI 1.20–3.57). Women born in Sub-Saharan Africa are at higher risk for GBS vaginal persistence than women born in France. This observation correlates with an increased prevalence of the hypervirulent GBS CC-17 in the former group, which likely reflect variations linked to ethnicity and vaginal community-state types and might account for the increased susceptibility of black neonates to GBS infections.

Details

ISSN :
14354373 and 09349723
Volume :
40
Database :
OpenAIRE
Journal :
European Journal of Clinical Microbiology & Infectious Diseases
Accession number :
edsair.doi...........667ceac138fabf71efa5c3582025cb33
Full Text :
https://doi.org/10.1007/s10096-020-04011-6