Back to Search
Start Over
Post Intensity-Modulated Radiation Therapy Urinary Function for Prostate Cancer; A Prospective Study
- Source :
- International Journal of Cancer Management. 13
- Publication Year :
- 2020
- Publisher :
- Briefland, 2020.
-
Abstract
- Background: At present, there is a lack of evidence concerning urinary complications caused by intensity-modulated radiation therapy (IMRT) used for the management of prostate cancer (PCa). Objectives: This study aimed at identifying the nature and severity of post-IMRT urinary symptoms in patients with PCa. Methods: This prospective study was performed with consecutive patients, who had clinically localized PCa (cT1c-cT2c) and had undergone IMRT treatment from 2016 to 2019. At 1, 6, and 12 months of follow-up, medical history, physical information, prostate-specific antigen values, International Prostate Symptom Score (IPSS), medication use, Radiation Therapy Oncology Group (RTOG), acute and late toxicity, and Q max were collected. Results: A total of 127 patients with a mean age of 71.04 ± 7.1 years received IMRT and underwent 12 months of follow-up. The mean IPSSs at baseline versus those at 1, 6, and 12 months after IMRT was 14.5 ± 6.8 versus 13.3 ± 6.1, 12.3 ± 5.3, and 10.4 ± 4.2, respectively (P < 0.000). The mean prostate volume was 38.2 ± 12.1 cc. At the last follow-up, 31 patients (24.4%) took genitourinary (GU) medications. Conclusions: This study showed that the majority of GU side effects caused by primary IMRT for PCa treatment are transient. Treatment triggered an acute increase in obstructive urinary symptoms, which peaked during the first month after IMRT. In most patients, in the course of 6 months, symptoms returned to baseline.
- Subjects :
- Cancer Research
medicine.medical_specialty
business.industry
Genitourinary system
medicine.medical_treatment
Urology
medicine.disease
030218 nuclear medicine & medical imaging
Management of prostate cancer
Radiation therapy
03 medical and health sciences
Prostate cancer
0302 clinical medicine
medicine.anatomical_structure
Oncology
Prostate
030220 oncology & carcinogenesis
medicine
Pharmacology (medical)
Radiology, Nuclear Medicine and imaging
Surgery
International Prostate Symptom Score
Urinary Complication
business
Prospective cohort study
Subjects
Details
- ISSN :
- 2538497X and 25384422
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer Management
- Accession number :
- edsair.doi...........6607ec18abf0f92785b19ed848c771e3
- Full Text :
- https://doi.org/10.5812/ijcm.102170