Back to Search Start Over

Post Intensity-Modulated Radiation Therapy Urinary Function for Prostate Cancer; A Prospective Study

Authors :
Saeed Montazeri
Morteza Fallah Karkan
Farzad Allameh
Amir Reza Abedi
Abbas Basiri
Bahram Mofid
Amirhossein Rahavian
Samira Azghandi
Source :
International Journal of Cancer Management. 13
Publication Year :
2020
Publisher :
Briefland, 2020.

Abstract

Background: At present, there is a lack of evidence concerning urinary complications caused by intensity-modulated radiation therapy (IMRT) used for the management of prostate cancer (PCa). Objectives: This study aimed at identifying the nature and severity of post-IMRT urinary symptoms in patients with PCa. Methods: This prospective study was performed with consecutive patients, who had clinically localized PCa (cT1c-cT2c) and had undergone IMRT treatment from 2016 to 2019. At 1, 6, and 12 months of follow-up, medical history, physical information, prostate-specific antigen values, International Prostate Symptom Score (IPSS), medication use, Radiation Therapy Oncology Group (RTOG), acute and late toxicity, and Q max were collected. Results: A total of 127 patients with a mean age of 71.04 ± 7.1 years received IMRT and underwent 12 months of follow-up. The mean IPSSs at baseline versus those at 1, 6, and 12 months after IMRT was 14.5 ± 6.8 versus 13.3 ± 6.1, 12.3 ± 5.3, and 10.4 ± 4.2, respectively (P < 0.000). The mean prostate volume was 38.2 ± 12.1 cc. At the last follow-up, 31 patients (24.4%) took genitourinary (GU) medications. Conclusions: This study showed that the majority of GU side effects caused by primary IMRT for PCa treatment are transient. Treatment triggered an acute increase in obstructive urinary symptoms, which peaked during the first month after IMRT. In most patients, in the course of 6 months, symptoms returned to baseline.

Details

ISSN :
2538497X and 25384422
Volume :
13
Database :
OpenAIRE
Journal :
International Journal of Cancer Management
Accession number :
edsair.doi...........6607ec18abf0f92785b19ed848c771e3
Full Text :
https://doi.org/10.5812/ijcm.102170